^^^This is a basic principle in dual pass heat exchanger/cooler design. Typically if a separator is not being used, it is on a design where the outlet and inlets are on opposite sides (single pass).
In a design like those shown in this thread, however (big square block with a common contact area, regardless of flow design), it's not going to make a big difference either way.
In a design like those shown in this thread, however (big square block with a common contact area, regardless of flow design), it's not going to make a big difference either way.



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